Installation of a patch will overwrite changes made to the configuration files, and update their version (indicated at the bottom of each file). Alternatively, you can archive the folder to avoid confusion. A good way to do this is to copy the Mass Effect or Config folder to a safe place. Those files will be prefixed with the word Default (to avoid editing them by mistake). By default they are located at 'X:\Program Files\Mass Effect\BioGame\Config'. If it fails to do so, or if the files have incorrect data, the game will read the default config files that are located in the folder where you installed your game. (%SystemDrive% will be replaced with the drive letter where your Windows system is installed on following a colon, and %Username% with the current user that you are logged into the system with.)
On Windows Vista/7/8/10: %SystemDrive%\Users\%Username%\Documents\BioWare\Mass Effect\Config.
All of the changes that are described in this article should only be tested on the files in the documents folder: